Bernstein test


The Bernstein test is a method to reproduce symptoms of heartburn . It is usually done with other tests to measure esophageal function .

Alternative Names

Acid perfusion test

How the test is performed

The test is done in a gastroenterology laboratory. A nasogastric (NG) tube is  through one side of your nose and into your esophagus. Mild hydrochloric acid will be sent down the tube, followed by salt water (saline) solution. This process may be repeated several times.

You will be asked to tell the health care team about any pain or discomfort you have during the test.

How to prepare for the test

You should not eat or drink anything for 8 hours before the test.

How the test will feel

You may have a gagging feeling and some discomfort when the tube is put into place. The acid may cause symptoms of heartburn. Your throat may be sore after the test.

Why the test is performed

The test tries to reproduce symptoms of gastroesophageal reflux (stomach acids coming back up into the esophagus). It is done to see if you have the condition.

Normal Values

The test results will be negative.

What abnormal results mean

A positive test shows that tyour symptoms are caused by esophageal reflux of acid from the stomach.

What the risks are

There is a risk of gagging or vomiting.

Special considerations


Fass R. Evaluation and diagnosis of noncardiac chest pain. . 2008;54:627-641.

Kahrilas PJ, Pandolfino JE. Esophageal neuromuscular function and motility disorders. In: Feldman M, Friedman LS, Brandt LJ, eds. . 9th ed. Philadelphia, Pa: Saunders Elsevier; 2010:chap 42.

Encyclopedia content is provided as information only and not intended to replace the advice and instruction from your personal physician.