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Hemolytic crisis

Definition

Hemolytic crisis is the rapid destruction of large numbers of red blood cells (hemolysis ). The destruction occurs much faster than the body can produce new red blood cells.

Alternative Names

Hemolysis - acute

Considerations

During a hemolytic crisis the body cannot make enough red blood cells to replace those that are destroyed.

This causes acute and often severe anemia .

The part of red blood cells that carries oxygen (hemoglobin ) is released into the bloodstream, which can lead to kidney damage.

Common Causes

Causes of hemolysis include:

  • A lack of certain proteins inside red blood cells
  • Autoimmune diseases
  • Certain infections
  • Defects in the hemoglobin molecules inside red blood cells
  • Defects of the proteins that make up the internal framework of red blood cells
  • Medication side effects
  • Reactions to blood transfusions

Call your health care provider if

Call your doctor or nurse if you have:

  • Symptoms of anemia, including pale skin or fatigue, especially if these symptoms get worse
  • Urine that is red, red-brown, or brown (tea-colored)

What to expect at your health care provider's office

Emergency treatment may be necessary. This may include a hospital stay, oxygen, blood transfusions, and other treatments.

When your condition is stable, your doctor or nurse will perform a physical examination and ask questions about your medical history and symptoms. The physical exam may occasionally show swelling of the spleen (splenomegaly ).

Tests that may be done include:

References

Schwartz RS. Autoimmune and intravascular hemolytic anemias In: Goldman L, Schafer AI, eds. . 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 163.

Gallagher PG. Hemolytic anemias:  red cell membrane and metabolic defects In: Goldman L, Schafer AI, eds. . 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 164.

Schrier SL, Price EA. Extrinsic nonimmune hemolytic anemias. In: Hoffman R, Benz EJ, Shattil SS, et al., eds. . 5th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2008:chap 48.

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    Encyclopedia content is provided as information only and not intended to replace the advice and instruction from your personal physician.