Search

Ectopic ADH secretion

Definition

Ectopic ADH secretion is the release of Antidiuretic hormone (ADH), or vasopressin, from an abnormal place in the body. ADH is a substance produced naturally by the hypothalamus and released by the pituitary gland. This hormone controls the amount of water your body removes.

Ectopic means "out of place."

Alternative Names

SIADH; Syndrome of inappropriate antidiuretic hormone secretion

Causes, incidence, and risk factors

The most common cause of ectopic ADH secretion is cancer. Certain lung cancers, as well as some head and neck tumors, are the most common cancers that cause this problem. In rare cases, many other tumors may cause ectopic ADH secretion.

See also:

Symptoms

The abnormal release of ADH makes it harder for the body to remove water. Fluid builds up in the body. Low blood sodium levels (hyponatremia) can occur.

Often, there are no symptoms from low sodium levels. However, changes in mental status and even seizures may occur.

Signs and tests

Treatment

Treatment is aimed at removing the cause of the problem (for example, surgery to remove a tumor producing ADH).

Limiting fluid intake is another common treatment. This helps prevent excess water from building up in the body.

Patients in the hospital with ectopic ADH that does not respond to other treatments may be given tolvaptan by mouth (orally) and conivaptan through a vein (intravenous). These treatments block the effects of ADH.

Support Groups

Expectations (prognosis)

Complications

Calling your health care provider

Prevention

References

Stewart PM, Krone NP. The adrenal cortex. In: Kronenberg HM, Melmed S, Polonsky KS, Larsen PR, eds. . 12th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 15.

Media

    Encyclopedia content is provided as information only and not intended to replace the advice and instruction from your personal physician.