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Carpal Tunnel Biopsy



Carpal tunnel biopsy is a test in which a small piece of tissue is removed from the carpal tunnel (part of the wrist).

Alternative Names


Biopsy - carpal tunnel

How the Test is Performed


The skin of your wrist is scrubbed and injected with medicine that numbs the area. Through a small cut, a sample of tissue is removed from the carpal tunnel. This is done by direct removal of tissue or by needle aspiration.

Sometimes this procedure is performed at the time of carpal tunnel release.

How to Prepare for the Test


Your doctor or nurse may ask that you not eat anything for a few hours before the test.

How the Test Will Feel


You may feel some stinging or burning when the numbing medicine is injected. You may also feel some pressure or tugging during the procedure. Afterward, the area may be tender or sore for a few days.

Why the Test is Performed


This test is usually done to see if you have a condition called amyloidosis. It is not usually done to diagnose carpal tunnel syndrome.

Normal Results


No abnormal tissues are found.

What Abnormal Results Mean


An abnormal result is a sign of amyloidosis.



  • Bleeding
  • Damage to the nerve in this area
  • Infection (a slight risk any time the skin is broken)



If the carpal tunnel biopsy reveals a problem, your health care provider may suggest a carpal tunnel release procedure. Additional surgery to correct or improve the problem may be recommended.


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